IRIS Registry-AGS Research Initiative


Application Cycle Closed.

The IRIS Registry-AGS Research initiative seeks to provide funding for qualified investigators to pursue important glaucoma research questions by utilizing the data in the AAO’s IRIS Registry.

The American Academy of Ophthalmology’s Intelligent Research In Sight (IRIS) Registry is the nation's first EHR-based clinical data registry devoted to eye care. The scope of the IRIS registry makes it a potentially valuable resource for research projects.

To facilitate such research, the Academy has established a process for investigators to propose projects that use IRIS data.

Proposals for analyses of IRIS data by the AGS Research Initiative should address large questions that are important to AGS physicians, our glaucoma patients, enhance and advance the care of our patients, and should also advance the mission of the AAO as required by the IRIS Registry research review committee:

 The mission of the American Academy of Ophthalmology is to protect sight and empower lives by serving as an advocate for patients and the public, leading ophthalmic education, and advancing the profession of ophthalmology.

Investigators may submit proposals to the AGS and will be reviewed by an AGS review committee familiar with IRIS Registry and big data investigations.

Funded study would have the following attributes:

  1. Important clinically-focused research on glaucoma patients within IRIS that has the potential to positively impact glaucoma care. Special consideration will be given to projects that investigate comparative effectiveness of glaucoma treatments. 
  2. No external funding source unless the investigators intend to combine datasets from outside sources with the IRIS Registry data. Internal institutional support is encouraged and is acceptable. 
  3. Grant applications will be accepted by all institutions, if a grant application comes from a person/group at an institution that has a data analytics center award from the AAO, $50k funding would be remitted to the analytic center directly. If an application is from outside one of those institutions, or the data center institution was not willing to prioritize the AGS project, then $50K Analytics funding will be remitted to AAO data scientists to do the work. 
  4. Principal Investigators must be either AGS active or provisional members and current with membership dues.
  5. Completion of the study within 2 years after acceptance by the IRIS Registry review process, submission for publication as specified by the IRIS Research committee (right of first refusal by Ophthalmology journal), presentation at either the AGS Annual meeting or the AAO Glaucoma Subspecialty Day.
  6. Total budget not to exceed $75,000. $50,000 of funding for the research proposal budget should be allocated to obtain data analysis by the IRIS Registry (or other AAO affiliate as describe in #3). This grant does not support indirect costs.
  7. Investigators agree to share the resulting data analysis with future AGS-sponsored investigators for expansion of the initial research.